Understanding the Link: Insulin Resistance and Cancer

Insulin resistance is a term that is familiar to people with Type 2 Diabetes, but its implications go beyond blood sugar control. It's a condition where the body's cells don't respond effectively to the hormone insulin. This means glucose (sugar) struggles to enter cells, leading to a buildup in the bloodstream and, eventually, Type 2 Diabetes.

A growing body of research suggests a concerning connection between chronic hyperinsulinemia (an increased state of insulin in the blood) and the development of certain cancers, including colorectal, pancreatic, endometrial, and breast cancers. 

But how are they linked?

The primary mechanism involves insulin's role in promoting the production of Insulin-like Growth Factor 1 (IGF-1). In a state of over-nutrition, elevated insulin levels and IGF-1 can trigger cell proliferation, a key feature of cancer growth. Additionally, hyperinsulinemia can disrupt the balance of sex hormones like androgen and estrogen, which are known to influence the growth of some cancers.

For metabolic health and possibly to lower the risk of cancer, insulin resistance must be corrected. The secret is to increase insulin sensitivity, or the cells' capacity to react to insulin efficiently.

Signs of insulin resistance

• A large waistline (over 40 inches for men, 35 for women)
• High blood pressure (at least 130/80 mmHg)
• Increased triglycerides (over 150 mg/dL) and fasting hyperglycemia (above 100 mg/dL)
• Low HDL cholesterol (the "good")
• Acanthosis nigricans, or black, velvety skin patches, or skin tags

Addressing the root causes

Chronic stress, obesity, sedentary lifestyles, and diets heavy in refined carbohydrates are common causes of insulin resistance. Hormonal imbalances, smoking, binge drinking, and poor gut health are additional contributing factors.

Lifestyle changes to improve insulin sensitivity

Transform your health journey with practical, everyday lifestyle adjustments that stick.

• Diet: Pay attention to portion quantities and give complex carbohydrates priority over simple ones. Pay attention to foods that have a low glycemic load. Boost your consumption of plant-based fibre and include healthy fats from foods like nuts, seeds, and fatty salmon.
• Exercise: One of the most effective ways to increase insulin sensitivity is to exercise. Resistance training combined with aerobic workouts (such as walking or cycling) has a major beneficial impact.
• Holistic Health: Avoid smoking and binge drinking, manage stress, and get adequate sleep. Using probiotic and prebiotic foods to support gut health can also have an impact.

Remember, medications may help, but long-term health hinges on a commitment to a healthy lifestyle. By taking proactive measures to improve your insulin sensitivity, you're not only managing your blood sugar but also taking a significant step towards reducing your risk for chronic diseases, including certain cancers.