Experiencing depression during cancer treatment is quite common. But the depression that you face is not always caused by the emotional stress of the diagnosis alone. Sometimes, the treatment that you go through can trigger inflammation throughout your body, which may lead to the release of immune proteins called cytokines. These signals can affect how your brain works and demoralize you. This is why it is crucial to know the reason behind your depression.
How does inflammation affect your brain?
Inflammation during your treatment can make your body release proteins called cytokines. It is a part of the natural immune response. These cytokines can travel through your brain and influence chemicals responsible for regulating your mood. But when these chemicals become affected or imbalanced, you may experience loss of interest, low motivation, or sadness. All of this can make you feel depressed, even if your body is responding well to the treatment.
Which cancer treatments may trigger inflammation?
There can be several cancer treatments that can increase inflammation as they attack cancer cells.
Chemotherapy can rapidly destroy dividing cancer cells, which can trigger the release of cytokines
Immunotherapy can activate immune responses, sometimes even leading to inflammation
Radiation therapy can localize inflammation when tissues repair themselves
The body’s healing process after your surgery can also cause inflammation
Managing depression
Depression during your cancer treatment is quite common, and in most cases, it can be treated. For this, you need to pay attention to yourself and recognize early persistent symptoms like sadness, changes in sleep, appetite, or feelings of hopelessness. If these symptoms continue for more than two or three weeks, then it is better if you seek your doctor’s aid. With professional counselling, support groups, and some stress-management techniques, depression can be managed. Early recognition in this case can help you improve your emotional well-being before it’s too late.
What does research have to say?
Inflammation can contribute to your depression during cancer. But that is not the only cause, as several factors can be involved. Emotional stress, pain, and fatigue can also cause a chemical imbalance in your brain. A study published by the National Library of Medicine in September 2024 states different therapeutic strategies for treating cancer-related depression. By combining cancer treatments with mental health practices, your depression can be improved.
Gaining your spark back
Depression during your cancer treatment can feel like losing hope in life, but it is actually your body’s response to the treatment. By recognizing early changes and seeking timely medical help, recovery can feel much easier. With the right support, your mind will find calmness, and your life will gain its meaning.